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Other situations in which intramucosal acidosis could arise with preserved tissue perfusion are reperfusion injury [ 31] and cytopathic hypoxia generated by endotoxemia [ 32], with cellular damage and metabolic abnormalities as underlying mechanisms.
As mentioned by Dubin and coworkers [ 1], impaired villous microcirculation has been suggested [ 6] to be the causal phenomenon in cytopathic hypoxia [ 5], a situation in which intramucosal acidosis should theoretically arise with preserved tissue perfusion.
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11.One objective of hemodynamic treatment during esophageal/gastric varices rupture should be to restore a satisfactory mean blood pressure to preserve tissue perfusion (strong agreement).
In the phase of early resuscitation after a severe burn, it is of paramount importance to promptly restore vascular volume and to preserve tissue perfusion but minimize tissue edema [ 16].
In children, however, gastritis is frequently associated with portal hypertension [ 85]. 11.One objective of hemodynamic treatment during esophageal/gastric varices rupture should be to restore a satisfactory mean blood pressure to preserve tissue perfusion (strong agreement).
Transfusable fluids that may be used as alternatives to red blood cell transfusion offer the promise of preserving tissue perfusion and minimizing hypoxic cellular damage, and this promise may soon be fulfilled.
The biologic goal of transfusion therapy is to preserve tissue perfusion in order to minimize the damage – both physiologic and structural – that results from prolonged or repeated episodes of ischemia [ 1, 2].
Preserved tissue was placed in long-term storage at −80°C.
To study cellular interactions, preserving tissue structure is necessary.
In this intricate system, activated protein C plays a key role in preserving and restoring tissue perfusion through its potent antithrombotic, profibrinolytic, and anti-inflammatory properties [ 6- 8].
Although the authors did not design the study to assess potential mechanistic explanations for their promising results, diaphragmatic function was likely preserved due to improved tissue perfusion and decreased pro-inflammatory responses.
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