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First, our data are in line with previous observations that within a modular structure of neural networks involved in real-world representation, brain activity associated with personal familiarity shows a relatively preserved pattern across various stimuli such as faces, voices, places, and objects [1], [8], [10], [11].
Upon that, the CAPs belonging to families exhibiting a highly preserved pattern 3 usually show the same motif.
However, Figure 3 also evidences how the preservation of pattern 3 varies depending on the family and that many families characterized show poorly preserved pattern 3 motifs.
Finally, the motif's similarity between the empirically characterized flap and the highly preserved pattern 3 found in almost every, but not all, sequence logos suggests that the likeliest function for pattern 3 is flap.
This fact probably has a negligible effect to the overall biological conclusions but suggests that families showing poorly preserved pattern 3 motifs may enclose more protein isoforms, which should be characterized by separate HMMs and logos to clarify all possible pattern 3 variants.
Recently, many studies have suggested that biological network modularity arises from natural selection pressure or evolutionary constraint for adaptation to environmental demands [66] [68], thus leading to an interesting question that whether the brain modular architecture discovered here also reflects an evolutionary preserved pattern of brain functional organization.
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TLRs are evolutionarily preserved pattern-recognition receptors (9), expressed on several cell types including monocytes, predominant cells of the innate immune system that are pivotal in diabetes and atherogenesis (10).
The highly preserved patterns 3 present a wide range of motif variability that can be used to identify other patterns in the less preserved families.
To develop a thermoresponsive nanofabricated substratum, we sought to functionalize substrata engineered with our well-established capillary force lithography (CFL -based nanofabriCFL -basedhnanofabricationhermoresponsive release layer while preserving patechniqueslity.
Eastern Catholic churches generally have been associated with a national or ethnic group, preserving patterns of church organization, liturgy, and language as their traditions developed separately from those of Western Christian churches.
Here, Southeast Asia, as the further edge of the South China Neolithic, may preserve patterns long lost in the core area.
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Justyna Jupowicz-Kozak
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