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In contrast to the preserved cognitive performance in aged ACHE mutants described above, animals subjected to genotoxic stress by gamma-irradiation at 6 months of age showed early cognitive deficits 7 months later.
We combined task and rsfMRI with structural MRI-derived volumetric measures of disease load, and detailed clinical, cognitive, and motor assessment, and identified a potential compensatory network in which increases in right-hemisphere activation and connectivity predicted better preserved cognitive performance in HD expansion mutation-carriers with higher structural disease load.
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Furthermore, the data suggests that decreasing IL-6 induction of Nox2, or eliminating downstream superoxide production directly can preserve cognitive performance.
Exercise programs that are structured, individualized, higher intensity, longer duration, and multicomponent show promise for preserving cognitive performance in older adults.
Studies provide compelling evidence that exercise can modify metabolic, structural, and functional dimensions of the brain that preserve cognitive performance in older adults.
Although further research is needed, physical exercise interventions aimed at improving brain health through neuroprotective mechanisms show promise for preserving cognitive performance.
Evidence from both animal and human studies supports the role of physical exercise in modifying metabolic, structural, and functional dimensions of the brain and preserving cognitive performance in older adults.
Approximately half of the aged rats perform within the range of young demonstrating preserved cognitive function.
At early stages of TBI pathogenesis, it suppressed apoptosis in vivo and preserved cognitive function.
More recently pioglitazone also preserved cognitive function in AD [31].
Written consent and preserved cognitive functions were also mandatory.
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