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With further validation, CBF measures could potentially become useful markers of treatment effects at an individual level, indexing key physiologic brain changes to detect reversal of losses, preserved brain function, or continuing brain decline.
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Neuroprotective agents refer to substances that are capable of preserving brain function and structure.
This study was designed to determine how metabolic dysfunction might contribute to cognitive impairment and to reveal specific metabolic co-morbidities that could be targeted to preserve brain function.
Thrombolysis is the only effective treatment to restore blood flow and preserve brain function, accepted in the clinic.
Resveratrol can also preserve brain function in neurologically impaired rats [ 15, 16].
16 Folic acid and vitamin B supplements may help to preserve brain function.
TGF-beta signaling is a molecular mechanism which limit neuroinflammation, and activate TGF-beta in the peri-infarct cortex and preserve brain function during the subacute period after stroke [ 11, 36].
These data confirm the neuroprotective property of calcilytics to preserve brain functions by suppressing the CaSR activity in ischemic neurons.
The current investigation demonstrates that carnosine preserved brain mitochondrial function in a hyperammonemic environment.
In animal models of encephalomyelitis, fingolimod, acting via S1PRs, reduced disease severity, restored motor function, and preserved brain tissue [ 106].
Thus, control mechanisms that minimize the extent of the inflammatory reaction are necessary in order to help preserve brain architecture and restore function.
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