The use of differential equations preserves the continuous nature of biological variables.
The power β facilitates a soft-thresholding approach that preserves the continuous nature of the co-expression relationships [ 19- 21].
The use of continuous equations preserves the continuous nature of biological variables and the interactions between them, as well as the continuous nature of chronic disease.
Second, it preserves the continuous nature of the correlation information; alternative approaches based on thresholding the correlation coefficient may lead to information loss.
Weighted networks have the advantage of preserving the continuous nature of co-expression and co-methylation information, which is particularly useful when studying module preservation.
The power adjacency function preserves the continuous nature of the gene co-expression information and, leads to results that are highly robust with respect to the choice of beta.
Although the latter approach has the advantage of preserving the continuous nature of behavioural performance, both techniques are inherently unidimensional and do not consider the presence of co-occurring deficits (e.g. poor comprehension).
Although the nature of underlying lesion-deficit relationship in the present sample is not known, we opted for VBCM because this approach has the virtue of preserving the continuous nature of both behavioural and neural indices.
We also preserved the continuous nature of predictors included in the prognostic model whereas they were categorized in the other models with a relatively arbitrary cutoff value (13, 14, 18– 20, 30).
