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Therefore, the application of conservation of sequence analysis is able to distinguish between evolutionary restraints arising from the need to preserve protein function and those that arise from the preservation of the protein's structural environment.
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This could be an indication that in VP3, multiple amino acid substitutions are accommodated in a coordinated manner that preserves protein function and structure.
Furthermore, amino acid compositional similarities among mytilid species (or even between F-ORF sequences and protein-coding genes within a same genome) would not be expected from non protein-coding sequences since they are not subject to selective pressure to preserve protein structure and function [75].
Recombination events in this region preserve protein blocks of distinctive functions and contribute to convergence in VP1u and divergence of the rest of cap.
As such, conservation of the native disulfide bonds is essential to preserve protein structure and maintain biological function.
Specific recognition and disposal of damaged proteins while sparing native, undamaged ones is essential to preserve protein homeostasis and to avoid loss of muscle function.
Functionality is maintained at nearly 100%, underscoring mild processing conditions apt to preserve fragile protein function.
Layer-by-Layer (LbL) polyelectrolyte multilayer films are highly attractive as ultrathin biologic reservoirs, due to the capability to conformally coat difficult geometries, the use of aqueous processing likely to preserve fragile protein function, and the tunability of incorporation and release profiles.
However, detergent micelles are not optimal for preserving membrane protein function due to their highly dynamic nature, and thus, protein unfolding and aggregation in detergent micelles are commonly observed.
The stabilizing selection that characterizes these subfamilies can be ascribed to the plants need to preserve important protein functions [ 22, 23].
It has been demonstrated in the mouse that reduction of this repetitive region can preserve a normal protein function [ 21].
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