The success in this area has been due largely to state-dependent and use-dependent characteristics of the drug channel interaction such that the inhibitory effect is most pronounced at partially depolarized membrane potential, thus preserving normal function.
Such a treatment would preserve normal genitourinary function while providing sufficient therapeutic efficacy.
We conclude that the homeostatic mechanisms that preserve normal membrane function vary: (1) with the nature of the stress that perturbs fluidity, (2) with local conditions within each tissue, and (3) possibly with the thermal tolerance of individual species.
To preserve normal cell function, excess ROS must be constantly eliminated by seminal plasma antioxidants.
Therefore, to prevent ER stress, it is important to preserve normal ERAD function.
Mitochondria work as energy stations and signal transducers to preserve normal organism function, and increasing evidence shows that mitochondrial dysfunction contributes to skeletal muscle disorders.
Fractures of the tibial plateau involve a major weight-bearing joint, and their successful treatment requires the restoration of joint congruity in order to preserve normal knee function.
If cytopathic hypoxia is important in the pathophysiology of established sepsis and multiorgan dysfunction syndrome, then efforts in the future will need to focus on pharmacological interventions designed to preserve normal mitochondrial function and energy production in sepsis.
Fluid and imaging biomarkers of this pathology are currently being sought in order to confirm early diagnoses and, importantly, to identify individuals in the preclinical stage so emerging therapies ultimately have a chance to preserve normal brain function (Craig-Schapiro et al, 2008).
The aim of tissue engineering is to substitute damaged or diseased tissue with biologic alternates that can repair and preserve normal and original function.
