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To preserve normal cell function, excess ROS must be constantly eliminated by seminal plasma antioxidants.
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A major challenge in cancer therapy is to search or synthesise drugs that kill tumour cells while preserve normal cells.
Epigenetic therapy reverting aberrant acetylation or methylation offers the possibility to target preferentially tumor cells and to preserve normal cells.
Maintenance of the fidelity of genetic material is critical for preserving normal cell function and preventing tumorigenesis of normal cells.
The modulation of signalling pathways by antioxidants could thus help prevent cancer by preserving normal cell cycle regulation, inhibiting proliferation, inducing apoptosis, inhibiting tumor invasion and angiogenesis, suppressing inflammation, and stimulating detoxification enzyme activity [ 30, 82, 83].
Destroying tumor cells and preserving normal cells require a targeting system and monoclonal antibodies to improve the targeting ability of the nanoparticles.
We suggest that this helps to preserve normal or increased cell ATP content in acute inflammation.
Rapamycin (an mTOR inhibitor) has been used to counter the effects of PTEN deletion and inhibit the development of leukemia-initiating cells while preserving normal stem cell populations [ 99].
The objective of gene therapy for the treatment of cancer is to kill tumour cells but preserve normal tissue; therefore, the ideal gene therapy agent would be targeted for specific transduction of tumour cells and have specificity in its cytotoxic action.
Collectively, the current literature suggest that the anti-inflammatory effects of HDACi in vivo generally tend to target pathologic inflammatory responses while preserving normal immune cell function.
Genetic and pharmacologic approaches in cell culture and in vivo allowed us to conclude that maintenance of a proper RARαβ/γ balance is crucial for preserving normal epithelial cell homeostasis.
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