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The methylene violet analogues were evaluated for their ability to preserve mitochondrial function in Friedreich's ataxia (FRDA) lymphocytes.
This study suggests that very low concentrations of mitochondrial-targeted H2S (sub nM) induce positive bioenergetic effects, preserve mitochondrial function and cell integrity.
Luteolin (16) treatment exerted neuroprotection through mechanisms that decrease amyloid-β precursor protein (AβPP) expression, lower Aβ secretion, regulate the redox imbalance, preserve mitochondrial function, and depress caspase family-related apoptosis [101].
For example, H2S-therapy has been observed to preserve mitochondrial function in the heart muscle after I/R injury [176, 180], but it failed to increase mitochondrial biogenesis [180].
Some studies showed that uric acid might preserve mitochondrial function [ 25].
Current and future research would aim to further improve and preserve mitochondrial function.
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Flow cytometry revealed significantly higher mitochondrial membrane potentials in the treated subjects, suggesting preserved mitochondrial function.
We find that mild muscle mitochondrial distress preserves mitochondrial function, impedes the age-dependent deterioration of muscle function and architecture, and prolongs lifespan.
Hydrogen sulfide (H2S) is well known to protect the heart from ischemia reperfusion injury by specifically modulating the mitochondrial adenosine-triphosphate-linked potassium channel, thereby preserving mitochondrial function.
Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function.
Tremendous investments in basic research have been focused on preserving mitochondrial function in AD.
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