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In the 15 patients with two documented incidences of re-employment of the same DMARD (ten MTX courses and five courses of other DMARDs), we only used the first observed event for all analyses to preserve independency of observations.
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We used a clustering method in order to identify clusters of highly correlated genes, prior to feature selection and model building as we hypothesized that this would to reduce the number of variables, increase signature stability, allow platform independency and to preserve biological interpretation [ 8].
In general, a sound method of BNs combination should satisfy three fundamental criteria, that is, avoiding cycles, preserving the conditional independencies of BN structures, and preserving the characteristics of individual BN parameters, respectively.
preserve it forever?
We cannot preserve everything.
Save and preserve Russia.
Always talk, preserve life".
"Preserve what?" she said.
Let's preserve that".
Saints preserve us!
AJ: One of our biggest challenges is to maintain our independency.
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