However, it is possible that the telephone-based intervention set up in TUMC improved the management of side effects and secured the whole treatment, encouraging physicians to preserve dose-intensity.
An intermediate regimen that maximises oxaliplatin dose intensity by focusing on 5-FU dose modification and preserving oxaliplatin dose may be equally valid.
By cycle 6, only 33% of patients remained on full dose sunitinib; cisplatin and gemcitabine doses were well preserved, but dose delay was common.
Faced with a limited supply of the vaccine in New York City at this point in the season, doctors with the vaccine on hand say they have to preserve the doses for the elderly and the physically vulnerable.
Our finding that mixtures of Mn2+ and the decapeptide in bicarbonate buffer protected approximately 50% activity of the dodecameric glutamine synthetase (622 kDa) at 50 kGy (Figure 4E), supports that complex quaternary protein structures in aqueous solution can be preserved at doses of ionizing radiation which destroy nucleic acids (Figure 5 and S3A) [15] [16], [39], [39].
Based on the current review, however, there is insufficient information to know whether the effect is preserved with doses of less than 0.4 mg/kg.
A primary objective of IMRT is to reduce dose to selected normal tissue structures in an effort to preserve function, while maintaining full dose delivery to tumour targets.
In models of focal infarction, animals that were anesthetized with pentobarbital dosed to preserve an active electroencephalogram had equivalent reductions in infarct volume as those anesthetized to EBS [ 5].
A 25% pre-exercise and 50% postexercise rapid-acting insulin dose preserves glycemia and protects patients against early-onset hypoglycemia (≤8 h).
Lower-dose treatment could possibly preserve the allograft as primarily intended here, but high doses of raloxifene in combination with bisphosphonates, for example, might also be promising.
Although hyperglycemia raises the threshold of fasudil-induced PostC, high-dose fasudil could preserve the protective effect.
