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Mathematical models have been developed to predict the probability of growth of spoilage moulds in response to various preservative systems in ready to drink beverages.
In this context, environmentally benign wood preservative systems can be developed with proper combination of an organic biocide with metal chelating and/or antioxidant additives (Schultz and Nicholas 2002).
Most spoilage incidents caused by yeasts are controlled by preservative systems [ 13].
The early time points, which assess the rate of kill of the challenge organisms, revealed the most significant differences between the two preservative systems.
Therefore, the presumed benefits of BAK-free otherher alternative preservative systems in terms of ocular tolerability remain to be clearly established.
This study was designed to characterize the antimicrobial performance of two commonly used topical ocular hypotensive agents that employ different preservative systems: latanoprost 0.005% with 0.02% BAK and travoprost 0.004% with sofZia, a proprietary ionic buffer system.
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One such example is travoprost Z, in which BAK has been replaced with the Sofzia preservative system.
An alternative preservative system, sofZia®, an ionic buffer that contains borate, sorbitol, propylene glycol and zinc [ 7], recently has been developed and approved by the U.S. Food and Drug Administration.
The rapid microbial reduction, along with the complete reduction of all microbial challenges with latanoprost ophthalmic solution with BAK, demonstrates that its antimicrobial activity exceeds that of travoprost with the sofZia preservative system and will afford greater protection against contamination and subsequent exposure to microbial insults during normal use.
The rapid and complete reduction of all microbial challenges demonstrates that antimicrobial activity of latanoprost with 0.02% BAK exceeds that of travoprost with sofZia preservative system in these products and provides a more protective environment in the event of contamination and subsequent exposure to microorganisms during use.
The aim of this research into above-ground (H3) fungal field testing was to find a method that would shorten the time required for evaluating new preservatives and protection systems.
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