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Preservation of inner retinal circuitry is critical to the fidelity of this transmitted signal to ganglion cells and beyond to higher visual targets.
OCT examination of focal light damage, well demarcated by the autofluorescence pattern, revealed a practically complete loss of photoreceptors with preservation of inner retinal layers, but also more subtle changes like edema formation.
In the majority of OPA1 patients the ECochG response begins with an abrupt deflection with peak latency and amplitude falling within the range of summating potential latencies and amplitudes in controls with normal hearing, a picture consistent with preservation of inner hair cells.
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This is mandatory to give the possibility for future treatment options for diseases of the inner ear, for example, to place devices like drug delivery systems, electrodes, or optical fibers with preservation of existing inner ear function such as hearing or balance [ 1– 3].
Preservation of existing inner ear function such as hearing or balance during this process is required.
Post-mortem studies suggest that although the disease damages the photoreceptor layer, there is moderate preservation of the inner nuclear layer, and relative sparing of the ganglion cell layer [ 4, 5], with evidence of significant changes in interconnectivity between cells of different layers [ 6].
Because optimal preservation of middle versus inner ear involves incompatible procedures, these were examined in different animals, using somewhat different methods.
Retinal OCT imaging demonstrated preservation of the photoreceptor inner segment/outer segment (IS/OS) junction at the fovea, with loss of this layer in the parafoveal region (Fig. 1A).
The soldiers' musical and physical training is strictly regimented; they must take satisfaction in the obedience to the laws in the preservation of the city's inner and outer peace and in deeds of valor in war.
In electrocochleography recordings, cochlear microphonic had enhanced amplitudes while summating potential showed normal latency and peak amplitude consistent with preservation of both outer and inner hair cell activities.
It has been suggested that the vasculature and greater oxygen tension of the outer meniscus can suppress cartilage-like matrix formation [ 41], and preservation of a chondrogenic phenotype similar to inner region cells may be contingent upon a hypoxic environment [ 42].
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