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Pulmonary and non-pulmonary factors may explain the preservation of exercise tolerance in patients with COPD associated with obesity.
Therefore, both pulmonary and non-pulmonary factors may explain the preservation of exercise tolerance in patients with combined COPD and obesity.
Sildenafil has been demonstrated in patients with idiopathic pulmonary fibrosis and right ventricular dysfunction to improve quality of life and preservation of exercise capacity [ 88].
Some animal studies reported the preservation of exercise benefits [ 8, 20], whereas others have shown the loss of the exercise-induced bone gain after the termination of exercise [ 21, 22].
In a randomized trial examining the effect of sildenafil on 6MWD in patients with advanced IPF and a DLCO below 35%, treatment was associated with preservation of exercise capacity in patients with RV systolic dysfunction as compared with placebo.
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Equivocal findings were reported with regard to preservation of exercise-induced bone gain after the exercise intervention was terminated.
Phinney SD, et al. The human metabolic response to chronic ketosis without caloric restriction: preservation of submaximal exercise capability with reduced carbohydrate oxidation.
46 Brain regions that showed reduced gray matter and white matter volume with age were closely mirrored by brain regions that show preservation of volume with exercise.
Preservation of effect from functional exercises has also been demonstrated in community-dwelling elderly women [ 43].
Addition of exercise significantly enhanced tissue preservation in the unirradiated group from 26.1% to 35% (p = 0.026) and in the irradiated group from 35% to 56.3% (p = 0.003).
Studies in Otsuka Long Evans Tokushima Fatty (OLETF), Goto-Kakizaki (GK), Zucker fatty (ZF) and ZDF rats have shown improvements in whole-body insulin sensitivity and preservation of β-cell mass with exercise training [ 104, 105].
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