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Schizophrenia presents unique difficulties in clinical trial design associated with the condition's variable presentation and clinical course, and multiple features influencing affect, cognition, volition and perception.
When the ankle is involved, limb salvage presents unique difficulties both in terms of biomechanics and soft-tissue coverage.
Background context: The management of lesions at the craniocervical junction presents unique difficulties for the spine surgeon.
For example, single cell qPCR requires normalization to single copy reference genes and control populations, which presents unique difficulties in assessing mosaic neuronal populations.
Chronic fatigue syndrome (CFS) is a debilitating illness [ 1] that presents unique difficulties for healthcare providers because there are no diagnostic signs, laboratory abnormalities or biomarkers and management aims to improve symptoms; no definitive therapy has been identified.
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Furthermore, burn wounds are complex and can present unique difficulties that require late intervention or life-long rehabilitation.
Such a large network inference challenge not based on synthetic simulations but on real data presented unique difficulties in scoring and interpreting the results.
The "Classic" size presents some unique difficulties because of the size of its view screen and clickwheel.
The coexistence of children representing opposite sides of the energy balance equation presents a unique difficulty for public health policy and interventions in Mauritius.
Integrating wind generation into power systems and wholesale electricity markets presents unique challenges due to the characteristics of wind power, including its limited dispatchability, variability in generation, difficulty in forecasting resource availability, and the geographic location of wind resources.
As dramatic actors within a narrative, aliens pose unique difficulties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com