Sentence examples for presents substantial difficulty from inspiring English sources

While T. gondii has an intron rich genome and, consequently, presents substantial difficulty for gene prediction programs to properly identify gene coding regions, in C. parvum there are almost no introns and gene prediction is rather straightforward [ 20].

When a given causal variant is ultra-rare, however, this presents substantial difficulties.

Formation of these objects, either by core accretion or gravitational instability, presents substantial theoretical difficulties.

In the present case a substantial difficulty arises from the fact that, beside imposing the volume constraint ({mathcal H}^n(Q(Gamma ))=omega _n) and that the barycenter of (Gamma ) is at the origin, we have also to fix some second order quantities.

The time points of all participant-related actions to be taken during the study period are presented in table 1. Retaining participants in a clinical trial of long-term duration represents a substantial difficulty for research teams.

These results show the substantial difficulty associated with the aim of searching for all published cases.

Our recent parameterizations were designed to pose substantial difficulty to inference from the AFS.

This can cause substantial difficulties in obtaining results which are easily presentable.

Participants encountered substantial difficulties with the inflexibility of the diagnostic equipment.

Substantial difficulties due to nonidentical relative degrees and directed interaction graphs are surmounted in this result.

The membrane itself may play a role but creates substantial difficulties for structural studies.