Sentence examples for presents significant limitations from inspiring English sources

However, it presents significant limitations such as insufficient immunopotentiation in comparison to other adjuvants, incapability to induce appropriate Th1-mediated and CTL cellular responses, and the risk of inducing allergic-type eosinophilic responses and granulomatosis.

The prokaryotic phage display technology is the method of choice when studying non complex proteins but presents significant limitations in the case where folding, post-translational modification or oligomerization of the gene products are needed.

Despite these obvious advantages of the large mammal model, the lack of large mammal genomic sequence data presents significant limitation for genome-wide analysis of gene expression profiles by microarray techniques.

Compared to the behaviour of unreinforced thermoplastics, short fibre reinforced composites present significant limitations at velocities close to the ballistic limit, but multi-hit capability is observed at high impact velocity when the damage is mainly local.

Standard two-dimensional cell cultures for testing effects of anticancer agents are simple and convenient, but present significant limitations in reproducing the complexity and pathophysiology of in vivo tumor tissue [ 2- 8].

Unfortunately, our experimental design presents significant technical limitations that prevent us to investigate epigenetic alterations based on the IUP and/or after exposure to dietary phytoestrogen during the fetal period.

This presents a significant limitation to our understanding of diet/nutrient inflammation interactions.

However, the proposed measure assesses disagreement only between two observers, which presents a significant limitation in observer agreement studies.

The inability of resequencing arrays to have high sensitivity for detecting novel indels, especially those involving only a few base pairs, presents a significant limitation [ 10- 12].

Propagation of elite varieties has been achieved through somatic embryogenesis (SE) but low efficiencies and genotype dependence still presents a significant limitation for its propagation at commercial scales.

However, although initial preclinical data are encouraging, the oral bioavailability of native tRes is relatively low, due in large part to its rapid conjugation, which presents a significant limitation to future clinical development of this potentially valuable drug.