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In the presented study normalization was performed using carefully chosen endogenous controls both for tissue and plasma analysis, which increases validity of our results.
It seemed to increase validity of the findings.
Expanding on our previous study by using four new years' worth of original data on exposure and end points confirmed our previously published results, 18 and therefore increased the validity of the present results.
However, this has the benefit of an increased external validity.
Team discussion increased the validity of the thematic analysis.
All of these steps increased the validity of the results.
However, the naturalistic setting contributes to increased ecological validity.
Single-center studies may, therefore, have increased intrinsic validity.
In the present study, we wanted to increase the validity of such microarray observations by performing additional RT-PCR and immunohistochemistry experiments and by linking our data to potential mechanisms of resistance to TNF blockade in RA.
A third strength of the present study consists in its regulations to increase internal validity.
This is the same concept that makes it possible to, besides separating the specialist auditors and others, increase the validity of studies, including the present study.
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