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Exact(1)
Others have reported the acquisition of antibodies that can block the activity of inhibitory antibodies [28], which may impede the development of inhibitory activity with increased exposure; presently, this effect is not well understood.
Similar(59)
Corticosteroids have been reported to affect the ROS production in PMN in a cumulative dose-dependent way [ 30], and it is presently unclear whether this effect is due to increased disease severity.
Presently, the effect of laser treatment is not clearly demonstrated and more basic and clinical research will be necessary.
Presently, the effect of oestrogen deprivation on CTX-II is based essentially on assessment of its urinary levels, and it has not been systematically analysed if these urinary levels reflect the local cartilage events where CTX-II originates from.
The mechanism behind this effect is presently unknown, but the effect was specific and not related to transfection efficiency as we did not detect a decrease in the miR-200b target ZEB2 in the condition in which PC-3 cells were transfected with the three LNAs (Supplementary Figure S3D).
Unfortunately we are presently not able to evaluate this effect compared to factors operating on each area in general, such as herd size, climate and management factors, all though we expect most cases of infection to occur during the grazing season, as a result of the close contact between animals at pasture.
We have investigated presently the effects of WT or mutant ASYN on the lysosomal pathways of CMA and macroautophagy in neuronal cells and assessed their impact on ASYN-mediated toxicity.
Presently, this ASCE Tsunami Loads and Effects chapter is applicable to the states of Alaska, Washington, Oregon, California, and Hawaii, which are tsunami-prone regions that have probabilistically quantifiable hazards resulting from tsunamigenic earthquakes of subduction mechanism.
Presently, we can only speculate about the exact mechanism for this effect.
As an extension to this, we presently elucidate the effect of 6-n-propyl-2-thiouracil (PTU-) induced hypothyroidism upon various relevant prooxidative and antioxidative parameters in adult rat liver SMP and mitochondrial matrix fraction along with histological and apoptosis analyses.
In addition, the paper presents an overview of environmental conditions used in safety analyses, as prescribed by diverse regulations presently in effect in Europe.
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