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Boaden is no stranger to the airwaves as a former host of Radio 4's Woman's Hour, but it is highly unusual for a senior BBC executive – creative director Alan Yentob excepted – to appear in a presenting capacity.
Their amount, phagocytic function, and antigen presenting capacity increase with gestational age (GA) [5, 10].
It is unknown whether GA affects dendritic cells (DCs), which, besides strong antigen presenting capacity, orchestrate Th1 and Th2 responses.
For this reason, it is critical to define the time interval when presenting capacity values and to never compare capacity values that were developed from different time durations.
We discuss the current status of clinical trials and new approaches to exploit the antigen presenting capacity of DC to design vaccines of the future.
We found that similar to migrant Gr-1+ MoDC the CD8αα+ LNDC had modest antigen presenting capacity.
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However, while this enhanced the efficiency of cross-presentation in CD103+ DC, it failed to induce cross-presenting capacity in Id2-GFP+Sirp-α− DCs from wild-type mice or DCs derived from Batf3−/− bone marrow.
These data demonstrate a clear trend toward a more efficient cross-presenting capacity of IFNα MoDC for soluble protein, in line with previous reports [ 13, 14].
The DC compartment has also been shown to exhibit increased number of immature cells with impaired antigen-presenting capacity (Pinzon-Charry et al, 2005a, 2005d).
This may include determination of, e.g., ex vivo cellular cytokine release, phagocytosis activity, and/or antigen-presenting capacity.
As expected, DC-LMP1/CD40/Ldlr−/− chimeras (DC-LMP1/CD40) showed increased antigen-presenting capacity of DCs and increased T-cell numbers.
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