Twenty-four patients (24%) presented a high expression of nuclear β-catenin (18 moderate and 6 high) and 46 patients (47%) presented an absence of E-cadherin expression in the membrane.
Further histochemical staining has shown how, contrarily to breast cancer cells, meningioma cells present a high expression of progesterone receptors (PR) and only a weak positivity for ER [ 7– 9].
Total RNA isolated from skeletal muscle tissue of newborn Lewis rats was used as calibrator because neonatal muscle tissue, in contrast to adult muscle tissue, is known to present a high expression of the muscle specific markers desmin, MoyD and MEF-2d and GAPDH was chosen as endogenous control.
WiDr variants expressed high levels of p53 and WiDr B presented a higher expression of p53 than WiDr T, as detected by densitometric analysis.
Screen-detected tumors were more frequently estrogen receptor and progesterone receptor positive (87.8% vs. 57.4%, p < 0.001 and 73.1% vs. 36.4%, p < 0.001, respectively), presented a higher expression of bcl-2 protein (78.4% vs. 62.7%, p < 0.01) and were less frequently HER2/neu positive (14.6% vs. 26.3%, p < 0.05) (Table 1).
Regarding the expression of Treg markers, the results presented in Figure 2(a) show that iTreg cells that were generated in the presence of IL-2 but in the absence of RA (TIL-2) presented a higher expression of the CD39 ecto-5′-nucleotidase and CTLA-4 compared with the expression observed in Treg cells that were generated in the presence of RA (TRA and TILRA Treg cells).
In addition, SKBr3 cells present a high expression level of the human epidermal growth factor receptor 2 (ErbB-2).
In those, an expansion in the number of CD4+ and CD8+ T-lymphocyte subpopulations that present an higher expression of activation molecules such as CD25 and HLA-DR, a decrease in the expression of CD28 costimulatory molecule, compared to asymptomatic carriers [ 15, 26].
Some of them present a high expression level and compartment-specific expression (FC > 100) suggesting they play an important role in early folliculogenesis.
In the present study, we found that a high expression of 17HSD type 1 predicted late recurrence among ER-positive patients and apparently decreased benefit from prolonged tamoxifen treatment.
