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Two of the non-concrete prototypes presented "substantial" challenges, and the remaining two had "moderate" challenges.
Maintaining the strength of each of these components has presented substantial challenges in most communities since the inception of the Program.
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Statistical inference from such high dimensional data structure with the large number of variables and very few observations has presented substantial challenge.
"Persons with mental disabilities face significant challenges in removal proceedings, and these cases also present substantial challenges for immigration courts," he said in an e-mail message.
We present the Internet of Things as an emerging scenario that will present substantial challenges and opportunities in this field.
The utilization of these propellants for long duration in space presents substantial challenges in fluid management in the low g environment.
Because instantaneous electrical generation and consumption must remain in balance to maintain grid stability, this variability can present substantial challenges to incorporating large amounts of wind power into a grid system.
Functional genomics using RNAi is a particularly attractive technique for genomic mapping and annotation in plants because many plants are polyploid, which presents substantial challenges for more traditional genetic engineering methods.
Assessment of physical activity in population-based studies of children presents substantial challenges [ 61].
Yet this complex approach presents substantial challenges for rare targets such as FGFR2 amplification.
Bacteriophage taxonomic classification reflecting phylogeny presents substantial challenges because of genome mosaicism (Lawrence et al., 2002).
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