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The interplay between these different cells results in a coordinated immunological response that is highly efficient in pathogen clearance, recruitment of leukocytes to the liver, and antigen presentation to lymphocytes.
These tissues are associated with mucosal surfaces of almost any organ, but especially those of the digestive, genitourinary, and respiratory tracts, which are constantly exposed to a wide variety of potentially harmful microorganisms and therefore require their own system of antigen capture and presentation to lymphocytes.
It has been shown for example that in dendritic cells antigens endocytosed by Fcγ RIIB access a non-degenerative intracellular vesicular compartment that recycles to the cell surface facilitating antigen presentation to lymphocytes [35].
DCs are critical for the collection and processing of antigens for presentation to lymphocytes.
IFN-γ increases antigen presentation to lymphocytes via induction of HLA-DR expression on monocytes.
As discussed earlier, MHCs are the complexes APCs load antigens into for presentation to lymphocytes, along with co-stimulatory signals.
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Antigen-presenting cells (APC), such as dendritic cells (DC), are well-equipped to phagocytose dying cells and process tumor antigens for presentation to T lymphocytes [3].
The availability of APCs (i.e., DCs and MΦs) in the skin may be a critical factor in shuttling antigen to lymphoid tissues and in its subsequent presentation to T lymphocytes.
Because lymphoid organs are settled by successive and different waves of innate cells likely to be involved in antigen capture and presentation to T lymphocytes, we examined whether the accessibility of MVA antigen to different APC subpopulations dictates the occurrence and extent of cellular immunity.
Several genes involved in antigen presentation to T lymphocytes were also found to be highly predictive.
Microbial or self-antigen presentation to T lymphocytes results in chronic activation of the immune system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com