Surprisingly, the results revealed that membrane-bound IL-15 forms present on human PB-HP [10], [12], in conditions favouring cell-to-cell contact, promote, through reciprocal trans-presentation, the generation of a novel subset of mature non-cytolytic NK cells.
It has been reported that DCs transfected with interleukin-12 and tumor-associated Ag-encoding mRNA were found to induce high avidity cytotoxic T-lymphocytes (CTLs) [35], and that DCs transfected with RNA encoding tumor antigens resulted in prolonged Ag presentation and the generation of high-affinity tumor-reactive CTLs [36].
At the end of presentation, the elder generation was speechless.
B. pseudomallei binding to its known receptor, TLR2, would activate the DCs, initiating the process of antigen uptake, processing and presentation required for the generation of protective immune responses.
This improved antigen delivery to professional APC augments antigen presentation and supports the generation of potent CD8+ cytotoxic T cell responses and CD4+ Th1 immune responses against an encapsulated antigen.
Hera is composed of two phases: the data collection phase, which integrates data from different sources, and the presentation generation phase, which builds a hypermedia presentation for the integrated data.
Upon cross-presentation, they prompt the generation of autoantibodies recognizing DNA (anti-DNA), RNP (anti-ribonuclear protein (aRNP)), LL37 peptide, citrullinated moieties (anti-citrullinated peptides (ACPA)) as well as MPO and PR3 (anti-neutrophil cytoplasmic antibody (ANCA)) [ 28, 30, 31].
We describe the multimodal presentation system WIP which allows the generation of alternate presentations of the same content taking into account various contextual factors.
Top-tier staff write proposals, manage funds and coordinate subaltern research units and are sometimes scarcely involved with the generation, presentation and discussion of results which is the core purpose of science.
Technologies focusing on the generation, presentation and application of clinical information in healthcare, referred to as health informatics or eHealth solutions [ 1, 2] have experienced substantial growth over the past 40 years.
With growing evidence that cross-presentation is crucial for the generation of appropriate CD8+ immune responses, future work should focus on uncovering the relevant mechanisms and better characterizing the dynamic nature of cross-presentation compartments.
