The essential parameters for the analysis of the relevant structures were the complete and clear presentation, the ability to estimate the degree of comminution and the degree of displacement.
It also alters the function of dendritic cells and other APCs to downregulate antigen presentation and the ability of APCs to stimulate T-cell responses.
Surprisingly, the choice of vaccine adjuvant did not appear to alter the magnitude or duration of antigen presentation, despite the ability of CpG adjuvants to directly activate APCs (26– 26).
Moreover, the efficiency of self-antigen presentation depends on the ability of thymic APCs to process and present self-antigen, and the density of MHC and co-stimulatory molecules on the APC surface.
We then extended the approach, using a group presentation, to explore the ability of health workers in routine practice to identify consensus defined clinical signs.
This capacity to inhibit the antigen presentation depends on the ability of the pathogen to alter the trafficking or maturation of the Salmonella containing vacuole (SCV) inside the DC which in turn depends on the presence of functional SPI-2 and production of nitric oxide (NO) [40].
The most interesting feature of the uptake of HSP-chaperoned peptides by APCs is their availability for cross-presentation, which is the ability of exogenous antigens to enter endogenous loading pathway of MHC Class I molecules and thus prime CD8+ T cells [ 76– 80].
In conclusion, our experiments yielded no evidence that the alterations in class II MHC levels and their trafficking affected efficiency of antigen presentation per se, or the ability of mice to generate antibody responses.
Finally, our results suggest that growth-related changes in cell wall protein expression, as well as stress/virulence-related changes in the topology of surface protein presentation, may dynamically modulate the ability of this organism to interact with and recruit plasminogen and possibly other plasma-derived mammalian factors implicated in the progression of microbial disease, in vivo.
The aim of this work was to analyze the effect of presentation format and instructions on the ability of people with intellectual disability to identify individuals they did not know and had seen only briefly.
