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CD23, the low-affinity IgE receptor is widely distributed on cells and mediates IgE-related immune responses by enhancing IgE antigen complex presentation, regulating IgE synthesis and influencing cell differentiation and growth of both B and T cells.
At the Drosophila NMJ, Dlp acts as a co-receptor of the Wnt protein Wg to limit extracellular Wg availability and presentation, regulating NMJ development (Dani et al., 2012; Friedman et al., 2013).
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In addition, it would be interesting to challenge the immunological response of the homozygous mutant mice since stefin proteins are reported to modulate antigen presentation by regulating cathepsins [7].
In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo.
For each AKAP we have identified, possible mechanisms for regulating antigen presentation can be proposed.
A voluminous literature exists pertaining to the role of ROS in regulating antigen presentation.
HspBP1 deficient mice were used to verify the role of the co-chaperone in regulating antigen presentation on MHC class I molecules.
Thus it will be interesting to determine if anchoring of PKA to Ezrin might be regulating antigen presentation through integrin activation.
To determine if AKAPs have a function in regulating antigen presentation, we disrupted the PKA/AKAP interaction using the Ht31anchoring inhibitor and Ht31p control peptides.
Both the CD300 and the APLEC encoded genes are important pattern recognition receptors involved in antigen uptake and Ciita is important in regulating antigen presentation.
LBP and BPI both act as sensors for the bacterial cell-wall component lipopolysaccharide (LPS), coordinately regulating the presentation of LPS to its receptor, TLR4, and thus directing TLR4-mediated inflammatory responses.
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CEO of Professional Science Editing for Scientists @ prosciediting.com