Sentence examples for presentation pathways from inspiring English sources
Furthermore, Harding and colleagues have shown, in vivo, that an extended OVA peptide, noncovalently associated with mycobacterial HSP70, could be presented via the MHC I presentation pathways of bone-marrow-derived murine macrophages and DCs to induce the secretion of IL-2 from a T-cell hybridoma specific for OVA peptide/MHC I complex [ 78].
Transcription analysis indicated that the TLR signalling pathway might play a major role in the innate immune response and the major histocompatibility complex (MHC -I and MHC -I andigen presentation pathways might also both exist in vertebrate fish.
To achieve this, we have investigated strategies designed to improve the immunogenicity of DNA vaccines encoding the Plasmodium yoelii pre-erythrocytic stage antigens PyCSP and PyHEP17, by targeting the encoded proteins to the MHC Classes I and II processing and presentation pathways.
My laboratory has begun to address this issue in virus infection models and a picture is emerging in which classical presentation plays a relatively minor role, with a number of alternative presentation pathways collectively accounting for the majority of peptide presentation.
Figure 3 depicts the two central pathways, i.e. the antigen presentation pathways, and the acute response pathway, and their relationships.
LAIV and TIV are administered through different routes and elicit CD8 T-cell responses through different antigen presentation pathways.
We have shown that exosomes activate CD8+ T cells, indicating that antigens present on exosomes can be processed through the class I MHC presentation pathway.
Therefore, alternative vaccine delivery systems, which enable introduction of nonreplicating antigen into the MHC class I presentation pathway, are sought.
The classical antigen presentation pathway consists of two monomorphic (proteasome and TAP) and one polymorphic components (MHC Class I).
Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway.
In mammals, the DM molecules are encoded by the major histocompatibility complex (MHC) and execute key functions in the class II antigen presentation pathway.
