Trastuzumab acts against HER2-positive tumors by multiple mechanisms, including receptor internalization, receptor 'shedding', direct anti-proliferative activity, antibody-dependent cell-mediated cytotoxicity (ADCC), and presentation of antigenic determinants of opsonized cells to antigen-presenting cells [ 6].
The in vivo specificity of hu3S193 for Ley on tumor cells and no saturable binding to any normal tissue compartment [20], indicates that the presentation of Ley determinants by tumor cells is different from normal tissues.
Efficient presentation of the cryptic determinants by monocytes was found to be mediated by FCγ RI [40].
This sounds like Frege's sense/reference distinction: The incomplete, auxiliary objects' role is akin to the role of Frege's sense, which functions as the mode of presentation and the determinant of its referent.
The study results suggest that social factors such as lower educational levels, lack of enough food and not on a disability grant are significant determinants in the presentation of HIV-related symptoms.
The following 13 presentations include overviews of molecular determinants of virulence of West Nile virus in North America, genetic determinants of Venezuelan equine encephalitis virus, evolution and dispersal of encephalitic flaviviruses, and West Nile and other zoonotic viruses in Russia.
We considered the possibility that the presentation of histones might be a crucial determinant of their actions and investigated the effects of substratum-bound histones on neuronal survival.
The etiology and pathophysiology of the circulatory compromise are among the primary determinants of the clinical presentation of patients with neonatal shock.
Additionally, logistic regression was performed to explore determinants of consent including presentation of baseline risk.
Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important.
