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Prophylactic in vivo concentrations (100 500 ng/ml liver plasma [157], [158]) inhibit antigen presentation in human antigen-presenting dendritic (DC) and B cells in vitro [159], [160], [161].
The Wall is a powerful presentation, in human terms, of the tragedy of the annihilation of European Jews.
A number of syndromes and drug effects exhibit sidedness of presentation in human patients.
It is TLR2 and TLR3 that directly promote the antigen presentation in human APC.
The distribution and amount of BPA and samples suggest a profile of ubiquitous presentation in human body.
It is likely that CD1a+cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a+cells in a large sample of all histological grades of human breast carcinomas.
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Meningitis is the most common presentation in humans, but septicaemia and endocarditis are also seen.
The clinical presentation in humans depends on the route of infection and varies from relatively mild skin lesions and lymphadenopathy to life-threatening pneumonia and/or septicemia [ 1].
Future studies will reveal how the effects on early cell movement (Fig. 1) correlate with disease allele penetrance and disease presentation in humans.
While we did see molecular and histologic evidence of building fibrosis with DD cells, we did not see the development of a frank tissue contracture analogous to the clinical presentation in humans.
Compared to carriers of other MAPT mutations, heterozygous R406W carriers typically show a later age at symptom onset (59.2 ± 5.5 years) with a protracted illness (12.7 ± 1.5 years), and milder frontotemporal atrophy on structural MRI. 12 Cell culture studies of R406W may reflect its milder presentation in humans.
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CEO of Professional Science Editing for Scientists @ prosciediting.com