Sentence examples for presentation function of from inspiring English sources
To circumvent this problem, many studies have focused on optimizing the antigen presentation function of DCs ex vivo such that these DCs can be adoptively transferred back into the in vivo environment.
The Tm/Cyt domains are essential for the standard antigen presentation function of class I molecules because they anchor the receptor structure into the cell membrane of altered self-cells where they can be recognized by CD8+ TC cells [1], [2].
Our results indicate that ginger extract suppresses the antigen presentation function of macrophages by decreasing MHC class II molecule expression.
To address whether the antigen presentation function of DCs is also compromised after capture of inflammatory neutrophils infected by a different organism, a RFP-expressing strain of Toxoplasma gondii was injected into the ears of LYS-eGFP mice.
IGHG3 could also combine with FcγRI on the surface of dendritic cells with high affinity, and enhance the antigen presentation function of dendritic cells to T lymphocyte [ 41– 41].
In support of this notion, a recent study showed that the antigen presentation function of B cells is critical for the pathology of experimental autoimmune encephalitis (EAE), more so than auto-antibody production [ 34].
Of note, infection with rMVA expressing OVA at high MOI increases only slightly the number of apoptotic cells and does not significantly affect the Ag presentation functions of DCs (data not shown).
Finally, while the effectiveness of EBV-targeted immunotherapy for virus-associated cases of EBV may be diminished by the inherent impaired antigen presentation functions of malignant cells [90], [102], small-molecule inhibitors of EBNA1 function represent a promising strategy in combination with other treatments [158].
Studying the antigen-presentation function of macrophages and DCs at later developmental stages is becoming increasingly feasible owing to advances in technologies for generating stable mutant lines (Clark et al., 2011; Blackburn et al., 2013; Kettleborough et al., 2013).
We explored the role of another receptor, CD300f, also involved in apoptotic cell clearance and in negative regulation of DC activation, to determine whether engagement of this receptor might also be required to suppress the cross-presentation function of DCs following their uptake of infected neutrophils in vitro.
Several theories have developed to explain the link between HLA-B27 and SpA, the classical example being based on its antigen presentation function and the possibility of molecular mimicry [ 1].
