28 Upstream, preventive strategies were seen as critical to improving the oral health status of these communities and the most effective way to reduce problem presentations downstream.
We used the S technology to explore whether the mode of ligand presentation affected the Notch downstream response.
Given the pleiotropic effects of IFNα/β pathway it is likely that some pathways, including MHC-1 presentation, may be affected downstream.
Forth, the output of DOGMA is not standard and requires reformatting for downstream data presentation or analyses, which can be a rather tedious step for experimental scientists.
Although a lot of time was devoted to how the oestrogen and other steroid receptors are activated after ligand binding, there were several presentations regarding the more downstream consequences of this activation.
However, little is known as to how modulating the spatial presentation of a ligand augments downstream immune responses.
There was no difference in MMSE scores between the two MCS1 groups, suggesting that cognitive function at ED presentation was not related to downstream mental quality of life.
Furthermore, CIA was ameliorated by delivering an adenoviral construct silencing PTEN directly to the inflamed joint, suggesting events downstream of antigen presentation [ 42].
Other relevant processes identified are those related to the immune system: PD1 signaling, antigen processing and presentation, CD4 T cell receptor signaling, downstream TCR signaling, phosphorylation of CD3, and TCR zeta chains among others.
In mammals, antigen processing and presentation are essential for triggering the downstream cellular and/or humoral immune responses [ 41].
