Animal models of inflammatory arthritis support an important role of B cells in disease pathogenesis through a variety of mechanisms, including aberrant antigen presentation and activation of autoreactive T cells in the joint [ 13].
The presentation and activation of CD4+ T cell response is highly efficient, even at very low concentrations of LLO, such as the picomolar or femtomolar range [ 18].
The replication of H. pylori within the cells can explain the endogenous antigen presentation and activation of CD8+ T differentiation post infection.
An exciting area of research has recently linked activation of TLRs on antigen-presenting cells (APCs) to effective antigen presentation and activation of naive T cells.
The role for exosomes in biological processes has garnered considerable attention recently, mostly in the context of tumor antigen presentation and activation of CD4+ and CD8+ T cells [34], [35], [36].
This study aimed to characterize the interaction of MVA and MVA expressing the HIV-1 genes Env-Gag-Pol-Nef of clade B (referred to as MVA-B) in human monocyte-derived dendritic cells (MDDC) and the subsequent processes of HIV-1 antigen presentation and activation of memory HIV-1-specific T lymphocytes.
In consequence, these cells should not specifically display an HCV-specific defect in term of antigen presentation and activation of HCV-specific T cells.
To address the function of H-2Kb molecular trafficking on antigen processing for presentation and activation of T cell responses, we evaluated T cell activation and proliferation following Listeria-OVA infection of DCs from transgenic mice in vitro.
Using the Ht31 inhibitor and Ht31p control peptides in DC loaded with protein or peptide antigen, we illustrate that type II PKA anchoring is necessary for optimal antigen presentation and activation of antigen specific T cells and activation of effector T cells in an allo response.
Additionally, we demonstrate that type II PKA binding to AKAPs is necessary for optimal antigen presentation and activation of CD4+ T cells, for TNF-α and IL-10 production, and for cell surface expression of costimulatory molecules, integrins, and the chemokine receptor CCR7.
