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Randomized controlled trials have the highest level of evidence in assessing a biomarker's benefit against usual care and present the most stringent design for the validation of promising markers as well as for the discovery of new markers.
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Thus, this step would be expected to exhibit the most stringent substrate requirements.
Above all else, it is, like the novels of McEwan and Ishiguro, a book about the present that fulfils the most stringent test of fiction as stipulated by Ezra Pound: that it brings news of how we live that stays news.
It is extraordinarily difficult to sign off on anything other than the most stringent option when presented with the intersection of clear threat and vulnerability.
The data presented in the figures suggest also that the most stringent thresholds are also the most valid, at least with regard to our definition of external validity.
This means that all whole brain results presented in this manuscript survive fdr correction at p<0.05, but are presented at p<0.001 (uncorrected) because this turned out to be the most stringent of the two.
It is worth mentioning that the most stringent assay applied in the present study is the in vitro differentiation assay that corresponds to the teratoma-formation assay in vivo.
In the present case, however, it is not possible to apply the most stringent conditions for each of the 5803 genes at the same time.
To avoid double-counting interactions present in 2 databases from the same source compiled with different stringency requirements, only the most stringent PITA and picTar microRNA prediction files were used as inputs into the integration and filtering steps.
Cronobacter genes were classified according to the most stringent settings of the trinary output of GACK as present, intermediate or absent.
The EPA case definition was the most stringent, followed by the UK and the Netherlands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com