IMPACT: The present study provides the first proof-of-principle evidence that AAV-U7-AONs remove a mutation in neonatal mouse cardiac myocytes and in vivo in the heart of a HCM mouse model.
The present study provides the first proof-of-principle evidence that AAV-U7-AONs remove a mutation in neonatal mouse cardiac myocytes (NMCMs) and in vivo in the heart of a HCM mouse model (Mybpc3-targeted knock-in (KI) mice).
The present study provides the first proof-of-principle evidence that disruption of the titin reading frame due to a truncating DCM mutation can be restored by exon skipping in both patient cardiomyocytes in vitro and mouse heart in vivo, indicating RNA-based strategies as a potential treatment option for DCM.
It preceded, by at least a generation, Archimedes' "On the Equilibrium of Plane Figures," which presented the first formal proof of the law of the lever.
The second proof of Theorem.
In this paper, we present the first self-contained and student friendly version of the Kronecker solver, with a substantially simplified proof of correctness.
We present herein a first proof of concept demonstrating the potential of a protein nanopore-based technique for real-time detection of selected Gram-negative bacteria (Pseudomonas aeruginosa or Escherichia coli) at a concentration of 1.2 × 108 cfu/mL.
We present herein a first proof of concept, to our knowledge, for the detection of two different Gram-negative bacteria (i.e., Pseudomonas aeruginosa and Escherichia coli) with a single α-hemolysin (α-HL) protein pore embedded in a reconstituted lipid bilayer.
Furthermore, data on 2D cell culture revealed that magnetisized VFFs can be controlled to grow only where a magnetic field is present as a first proof of concept.
(2) We present in "Second proof of Theorem 2.10" section which is more computational and longer.
