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The phrase "present substantial obstacles" is correct and usable in written English
You can use it to describe a situation in which someone or something is hindered from progressing or achieving a goal due to a significant challenge. For example, "The dire economic situation present substantial obstacles to achieving sustainable development."
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Isolated mixing regions (IMRs) are fluid regions that may or may not have interior mixing and are usually located far away from boundaries; however, they do not exchange material with regions of active global mixing and they therefore present a substantial obstacle to global mixing.
Trips to Dublin and Twickenham present significant obstacles, but not psychological barriers.
Critics of the law say it conflicts with the Supreme Court's 1992 decision in Planned Parenthood v. Casey, which ruled: "Unnecessary health regulations that have the purpose or effect of presenting a substantial obstacle to a woman seeking an abortion impose an undue burden on the right".
In Monday's ruling, the Court affirmed that the law presents "a substantial obstacle in the path of women seeking a previability abortion" and "an undue burden on abortion access".
"Unnecessary health regulations that have the purpose or effect of presenting a substantial obstacle to a woman seeking an abortion impose an undue burden on the right," read the lead opinion in Planned Parenthood v. Casey, a 1992 case that is now at risk of becoming dead letter if the Supreme Court deflects from a precedent called the "undue burden" standard.
The widespread inadequacy of national HMIS data sets presents a substantial obstacle to evidence-based public health decision making.
Dyslexia presents real obstacles to these students.
Often experimental measures of these parameters are unavailable, which presents significant obstacles for modeling.
Still, he faces substantial obstacles.
Ms. Bachmann would have substantial obstacles to overcome.
That may well be the case for Mr. McCain too, and he faces substantial obstacles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com