When ILS is present, gene trees can differ from each other and from the species tree, presenting substantial challenges to phylogeny estimation methods (Degnan and Rosenberg, 2009; Edwards, 2009).
Institutionalizing conservation planning will present substantial challenges, but none appear to be intractable.
Unfortunately, migration presents some substantial challenges to modelers.
While the promise of next-generation sequencing technologies has become a reality, they also present substantial challenges such as in the mapping of short sequence reads to the genome, polymorphism detection, characterization of allele frequencies from population samples and data management.
"Persons with mental disabilities face significant challenges in removal proceedings, and these cases also present substantial challenges for immigration courts," he said in an e-mail message.
We present the Internet of Things as an emerging scenario that will present substantial challenges and opportunities in this field.
A review of public health surveillance and response strategies also finds that health system factors including many identified in our study present substantial challenges in low- and middle-income countries, and that building sustainable programs requires long-term, sustained efforts [ 6].
An eruption of this explosivity today, depositing 5 10 cm of fine-grained ash (as was seen in these deposits; Table 2), would be unprecedented and present a substantial challenge to surrounding local and regional agencies, in terms of public health protection, clean-up (Hayes et al. 2015) and impact on infrastructure and utilities (Wilson et al. 2012).
Aspects of complexes involving ankyrin repeats, including featureless putative binding face surfaces and large binding interfaces, can present a substantial challenge to the development of small molecule inhibitors.
As such, dynamic changes in systemic blood pressure, such as those seen during both resistance and dynamic exercise, present a substantial challenge to cerebral homeostasis.
