The growing number of elderly people means more patients with multiple conditions - some of which, such as dementia, present significant difficulties in providing care and support.
There are various anatomic, physiological, and emotional factors peculiar to this age group that present significant difficulties and challenges for aerosol delivery.
The installation cost and the overall performance of the system strongly depends on the designing and dimensioning, which however present significant difficulties.
The hazards, safety concerns and radiowaste generation associated with using open-source radioactive isotopes can present significant difficulties, the use of hot cells and escalated costs in radioanalytical laboratory research.
Current techniques present significant difficulties in this perspective.
In addition, multiple medications and multiple daily administrations may be a necessary inconvenience and, for a subset of patients with dexterity problems, present significant difficulties to its use.
These properties, coupled with high abundance and high sample/local diversity are ideal characteristics of a monitoring taxon but if regional diversity is high, then this, coupled with immature taxonomy, could present significant difficulties for routine monitoring.
Collectively, these results suggest a shared molecular basis among fragile sites, indicating that the DNA sequences within these regions can present significant difficulties to the replication machinery, and require the activation of DNA damage checkpoint proteins.
Although the overall outcome was better in hypothermia patients in spite of the high infection rate, this indicates that use of hypothermia in these patients may present significant difficulties.
Two simple generalizations suggest that occupational exposures are several orders of magnitude higher than that of environmental exposures; and currently extant data and the current routine measurement practices present significant difficulties in the consistent interpretation of the data with respect to health effects.
