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The coordinate data used to create the rotating walker can be obtained from the present authors on request.

We were unable to obtain data on all outcomes (including answers to all questions, skin tests, lung function, AHR and FeNO) for all children; however, we found no significant differences in demographic characteristics between children with and without these data, suggesting that it is unlikely that this has influenced the results (not presented, available on request).

One-third (34 %) of mystery shoppers presenting the mild ARI scenario were inappropriately sold an antimicrobial and 85%% were sold one on request; encouragingly, 99%% presenting a case of pneumonia received either an antimicrobial, referral to a trained provider, or request to bring the child for examination.

Results were unchanged from those presented (results available on request).

To test the clinical hypothesis about an advantage of NPPV over SMT when using higher levels of pressure support ventilation [ 26], we performed a predefined subgroup analysis (Forest plots not presented but available on request) with stratification based on the level of pressure support ventilation (Pressure Support Ventilation – PSV ≥ 10.0 cmH2O versus PSV < 10.0 cmH2O; Table 3).

Age, gender and geographic origin were recorded as part of the standard information present on the laboratory request forms.

If parents reported child PTSS in the past, they were also asked if the symptoms were still present (results are not presented and are available on request).

Primer sequences used in the present study are available on request.

All cDNA plasmids, antibodies and recombinant proteins generated for the present study are available on request through our reagents website (http:s://mrcppureagents.dundee.ac.uk/).ac.uk/

All plasmids, antibodies and recombinant proteins that we have generated for the present study are available on request from our reagents website (http:s://mrcppureagents.dundee.ac.uk/).ac.uk/

All recombinant proteins, plasmids and antibodies generated for the present study are available on request and are described in additional detail on our website for reagents (https://mrcppureagents.dundee.ac.uk/).ac.uk/

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