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Although 10-fold greater quantities of antibody are required to observe significant effects in mouse, compared to our previous studies in rats, the present mouse model provides a convenient paradigm for investigating catalytic and non-catalytic antibodies.
CONCLUSIONS: Nicotine increases size and severity of experimental CNV in the present mouse model, possibly by potentiating PDGF-mediated upregulation of proliferation of choroidal smooth muscle cells or by other mechanisms.
Therefore, in the present mouse experiment, blood glucose was measured at 15, 30, 60, 90, and 120 min after oral intake.
The present mouse mutation will be a useful animal model for understanding the severe form of Silver-Russell syndrome (SRS) (OMIM 180860) [87].
In the present mouse model, the progressive loss of Clara cells occured during the rapid growth phase (0 4 wks) and was faster than loss of ciliated cells, as indicated by the expression of FoxJ1 and α-tubulin.
However in these two rat studies CPF was administered for longer periods than in the present mouse study.
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However, in the present mice fluid accumulated mostly in the subarachnoid space and to the extent that it compressed the brain from the outside.
When skull deformity was present, mice were sacrificed and the skulls were dissected and grossly examined by serial sectioning following decalcification.
Because the present mice were not reared under conditions of light deprivation, it does not necessarily follow that their mutations should produce blindness [ 34].
27 When all three loci are present, mice display a fully penetrant lupus phenotype that develops with age and is similar to the human disease.
On the second day, faculty and staff were all ears to keynote speaker, Dr. Timothy H. Murphy, a professor from the University of British Columbia as he presented "Mouse In Vivo Imaging and Optogenetic Tools for Elucidating Cortical Circuit Structure and Function Following Stroke".
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