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Indeed such variation in the number of present loci also contributes to the variability in the number of Mhc molecules.
However, because the loci in the study of Zhang et al. were mainly located with AFLP markers in an independent genetic map, it is difficult to determine the relationship of the present loci to them.
We included 73 RILs for which we could unambiguously determine the genotype for those specific genomic locations, i.e., no missing data or all present loci of one parental background.
This difficulty was overcome by taking into account the regional organization of the hybridization signal along the genome because, in spite of their weakness, successive signals of present loci are generally more intense than noises of absent ones.
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We present locus characteristics and examine genetic diversity in a larger sample size from 12 streams (i.e. populations) sampled within the northern range limit of D. tenebrosus in British Columbia (Latitude: 49°4'10; Longitude: -121°53'00).
An important outcome of the present locus-specific integrated reporter study is highlighted by bryostatin, which the previous, randomly integrated reporter assay failed to identify as an inhibitor of Pmp22.
Species such as T. fisherae and T. tabrisianum (Fig. 2k, n, asterisks), presented locus size differences, but in general, this was homogeneous.
At present, several loci 4q21 q24, 5q21, 6p12.2 p21.1, 11q24, 14q21.2 q22.3 and 15q11 q13 linked to common forms of migraine with evidence of linkage have been reported.
At present 121 loci are known to be involved in this phenotype [9], and for many of them the genes causing NSHL have not been identified yet.
Therefore, in cases showing genetic homogeneity despite great morphological divergence, genetic alterations might be present at loci other than those examined in the present study.
> -wrap-foot> In the present study, locus clusters were defined as regions in which ≥10 loci were mapped in 5 cM windows.
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