This study investigated a hypothesized correlation between contradictory responses from parental figures perceived in present-day interactions by adult subjects and the diagnosis of borderline personality disorder (BPD).
The 'Cultured Rainforest Project', an interdisciplinary project involving anthropologists, archaeologists and palaeoecologists, was set up in 2007 to investigate the long-term and present-day interactions between people and the rainforest in the Kelabit Highlands of central Borneo, so as to better understand past and present agricultural and hunter gatherer lifestyles and landscapes.
These noisy networks simulate the common scenario in which the measurement of present-day interactions is error-prone.
The network history inference problem seeks to find a set of gains and losses of protein interactions that is consistent with both the observed present-day interactions and the phylogenetic history relating the proteins.
Present-day interactions were created between those pairs for which the interaction score is ≥30.6 (the score for which the probability of an interaction existing given the score is 0.5) (Pinney et al., 2007).
The algorithm is applied to reconstructing ancestral interactions among bZIP transcription factors, imputing missing present-day interactions among the bZIPs and among proteins from five herpes viruses, and determining relative protein duplication order in the bZIP family.
In cross-validation tests, we find that our approach ranks the majority of the left-out present-day interactions among the top 2 and 17% of possible edges for the bZIP and herpes networks, respectively, making it a competitive approach for edge imputation.
Here, we present a general framework for inferring such histories and demonstrate how it can be used to determine what interactions existed in the ancestral networks, which present-day interactions we might expect to exist based on evolutionary evidence and what information extant networks contain about the order of ancestral protein duplications.
> -wrap-foot> These results show the potential benefit of using the SOPH approach to the ancestral network reconstruction problem, especially in the typical situation where the error rates of measured present-day interactions can be very high (Stumpf et al., 2007).
Present day mechanisms underlying interactions (e.g., protein exchange) between the cytoplasm and nucleus (pores), and between the cytoplasm and mitochondria (TIM/TOM), are very different.
