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In particular, at the frequency of 9.75 Hz, the coupling factor is extremely high (25 × 10−3); thus, any signal present at this frequency would be apparent in the gravimeter response, amplified by a factor of 0.025.
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These two insertions are in phase and are present at the frequency of 0.3342%.
However, our results suggest that two TCRβ V gene segments that were only reported to contain functional alleles were overwhelmingly seen as non-functional alleles in our cohort, suggesting the existence of novel pseudogenic alleles that are present at high frequency in this population.
The 539T allele was only present at a frequency of 0.002 in this population and this may explain our inability to confirm the association of this SNP with protection from TB reported in other populations [21], [20].
This haplotype, present at a frequency of 0.15, had an REHH of 2.7 at −68.3 kb from the core region which is supportive of the suggestion of positive selection for CYP2C19* 2. Since our genotyping data did not extend further than −68.3 kb from the core haplotype it was not possible to examine REHH over longer stretches of the genome in the Gambian study group.
Here we report that PIRM syndrome (ptosis, intellectual disability, retarded growth and mortality) in cattle is associated with an exon skipping mutation in UBE3B and this mutation is present at high frequency in the sample of AI bulls tested.
Present at low frequencies, this phenomenon illustrates contact with other varieties.
This 'lactase persistence' trait is present at high frequency in European, Middle Eastern and pastoralist African populations (reaching frequencies of up to 90% in northern Europe) (Swallow 2003).
This sub-haplogroup is usually present at low frequency in Siberian populations [ 15, 21, 22] and in Central Asian or Mongolian populations [ 23, 24].
Only one of these "loss" loci was present at a frequency of greater than 1% and this locus also overlapped a CNP.
The downside of this approach is the potential loss of true resistance loci present at low frequency (increase in false negatives).
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