The prevailing interpretation of these fundamental observations is that most, if not all, introns that occupy the same positions in orthologous genes are conserved, i.e. were already present in the equivalent position of the corresponding ancestral gene.
These include S21, T22, K154, S157 (GTP/GDP-binding site), S76 (eEF1Balpha-binding site; note Alanine (A76) is present at this equivalent position in yeast), R166 (mutant reduces dependence on eEF1B), N331S, M335Q and Y357 (mutants involved in actin bundling/organisation).
Table 2 presents a comparison of the residues of the proposed binding site for AR-C155858 in MCT1 with those at the equivalent position in MCT2 and MCT4.
The results are compared with those obtained using a fixed pipe at the equivalent position and at other positions including near the top surface, the most convenient position industrially.
Conservation of an arginine at the equivalent position across many plant kinases implies an important function for this residue [25].
Additionally, mouse COMT, which contains Leu instead of Val at the equivalent position as the human Val108/158Met polymorphism, has higher activity than the Val allele [8].
The R at the equivalent position (24) is shared in rhesus, but not AGM, tetherin.
The reader must guess what residue is at the "equivalent position".
In contrast to YePEPT, which has a Lys at position 314, GkPOT and PepTSt have both a Gly residue at the equivalent position.
In the structure of IbCO, an inhibitor (1-phenyl-2-thiourea) is located at the equivalent position [ 44].
