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Small cell lung cancer is the most aggressive form of the disease and very few patients ever present at a stage where surgery can be contemplated.
This means that contrary to early detection, women would present at a stage that usually requires aggressive treatment including chemotherapy and more often axillary dissection.
Although radical surgery could offer cure, fewer than a quarter of all patients present at a stage that can be treated surgically[ 2].
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Accordingly, a case can be made for routine PET/CT for at least baseline assessment of the vast majority of cancers, with relatively few cancers currently presenting at a stage where the likelihood of metastatic disease is very low.
Their co-production of Angélique will tour Ontario in 2019, and the French translation of the piece will be presented at a staged reading at Centre du Théâtre d'Aujourd'hui in December.
Younger women present at a later stage of disease, but that alone does not explain their worse survival since they also have a worse prognosis stage by stage.
Patients tend to be older, present at a later stage, and have a high incidence of comorbidities, which can compromise treatment delivery and exacerbate toxicity.
Rural patients with cancer are commonly thought to present at a later stage of disease, although this is based largely on anecdotal evidence.
Bilateral AVN occurs in 80% of cases and each side may present at a different stage.
If the costs of self-harm only present at a later stage in life, and cause acceleration in aging but not a reduction in median lifespan, then natural selection on reducing self-harm will be weak.
Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com