Sentence examples for present a substantial problem from inspiring English sources

However, as allele specific gene expression is due to differential DNA methylation, this may not present a substantial problem here, as Dipterans have lost the main methylation enzymes in their evolutionary history [ 43].

In short, the dearth of rural therapy services in Australia presents a substantial problem.

However, this presents a substantial problem in terms of the future computational requirements of the BOADICEA program.

However, compounds with artificial activity readouts are often not recognized and are further progressed, which presents a substantial problem for drug discovery.

Falls present a substantial health problem among the elderly population.

"The revelations present a substantial new issue," he said.

In this article we demonstrate how this is a substantial problem in practice and present a method that greatly helps ameliorate the problem.

The present dataset had few replicates, which creates a substantial problem in identifying true measurement noise and makes it difficult to pinpoint outlier values.

"It could become a substantial problem," he said.

"It's a substantial problem," Botstein recognized.

Neurological complications of paediatric cancers are a substantial problem.