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However, three compounds with at least ∼3-fold selectivity for GPRC6A were discovered, which present a significant step forward compared with the previously published GPRC6A antagonists, calindol and NPS 2143, which both display ∼30-fold selectivity for the calcium-sensing receptor compared to GPRC6A.
In this issue Dias-Santagata et al present a significant step forward in this direction by describing an optimized assay for identification of the most common oncogenic mutations (including EGFR, KRAS, NRAS, BRAF and PIK3CA).
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To this end, this paper presents a significant step towards bridging these gaps for one of the most important dialogue game types; namely argumentation-based negotiation (ABN).
The recent progress made in the structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis presents a significant step toward these goals.
The study presents a significant step forward towards a structural understanding of the autophagy process.
The plan announced in late 2003 as the Palestinian uprising against Israeli occupation entered its fourth year, was presented as a significant step toward a two-state solution, with Israel and Palestine, living side by side, in accordance with the goals of the internationally approved "road map" to peace.
The work here presented gives a significant step in this direction providing the first complete view of the expressed transcriptome of this specific human cell type isolated from two quite distinct tissue microenvironments: adult bone marrow and fetal placenta.
We present here a significant step forward, extending this initial work to the silicon nanomembranes described above.
The settlements present a significant shift.
This would represent a significant step beyond the current science.
The work presented herein is a significant step toward the modeling of strain-hardening composites that exhibit multiple cracking.
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