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Pooled clinical trials may provide a confirmation of the clinical features associated with the different patterns in a given diseases so that clinicians could use such profiles to identify patients with a low performance status at baseline but who could present a deterioration in their QoL.
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This paper presented a deterioration model that integrates the effects of chloride-induced corrosion, climate change and cyclic loading for RC structures.
Eight weeks after the initiation of vemurafenib treatment, the patient presented a deterioration in general health status and an elevation of liver transaminases and lactate dehydrogenase levels.
The hot-air heating system has been proved to present a potential deterioration risk to artworks, as it increases the supply, transport and deposition probability of air pollutants.
Studies have demonstrated a decreased expression and/or DNA binding activities of MafA and PDX-1 in diabetes and chronic hyperglycemia which present a gradual deterioration of pancreatic β-cell function [ 47].
In addition, muscle Vps15 KO mice did not present an overt deterioration in nutrient homeostasis, as indicated by the normal glucose tolerance test (GTT) and insulin tolerance test (ITT) (Supporting Information Fig. 4C and D).
It is important to note that this relation is also true for patients who did not respond to the first treatment course: if those patients present with a deterioration of symptoms, they might benefit from a second treatment course indeed.
He then presented a rapid deterioration of systolic function with an EF of 35% and treatment with ACE inhibitors was initiated.
Three months later, the patient presented a marked deterioration of his general condition.
Patient 6, who had a pulmonary ARDS and who before starting the study had a 30 mmHg CO2 gap while being ventilated with 4 cmH2O PEEP, presented a further deterioration in CO2 gap after starting the protocol with 10 cmH2O PEEP, which was not associated with a decrease in cardiac output.
Below, we present a case of reversible deterioration in renal function following treatment with the angiotensin II antagonist candesartan.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com