Sentence examples for present a challenging problem from inspiring English sources

In association with slow dissolution characteristics, poor permeability and/or the involvement of efflux transporters, poorly aqueous soluble/permeable drugs present a challenging problem for drug formulation development due to the limitation of drug absorption in the gastrointestinal (GI) tract.

Second, in spite of major breakthroughs in understanding the molecular basis of CRC, it continues to present a challenging problem in cancer medicine.

However, fiber-optic probes that require contact with the tissue surface can present a challenging problem in the variability of in vivo measurements due the nature of interactions, for example affects due to variations in pressure applied to the probe tip.

Intraarticular fractures of the distal radius present a challenging problem for surgeons.

Benign esophageal strictures refractory to standard dilation therapy present a challenging problem.

Assignment of structures to isoprenoids once presented a challenging problem because the method for determining the structure of an organic compound was based entirely on studies of chemical reactions.

C3-type distal femur fracture presents a challenging problem to orthopedic surgeons.

As a result, the gap in income between two social groups is going to widen even further, which presents a challenging problem for today's economy.

Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities.

Acute appendicitis presents a challenging problem to caregivers because it must be differentiated from a variety of other conditions that result in acute abdominal pain in childhood and the most common condition requiring emergency abdominal surgery in the pediatric population.

Adequate pedicle screw fixation in the presence of compromised bone quality presents a challenging problem for spine surgeons.