Despite encouraging preclinical data in cancer, clinical trials were unsuccessful mainly because of the lack of overall response and the presence of dose-limiting toxicity.
Further, our findings support that Pseudonocardia is a mutualist of the ant-fungus association, and suggests that cultivar growth inhibition in vitro (this study) is due to the presence of doses of compounds exceeding what occurs in the fungus garden (see above).
In addition, the presence of dose-response relationship strengthened the association of magnesium intake with risk of type 2 diabetes.
Our results were also in partial agreement with those obtained from studies on experimental animals that suggested the presence of dose-dependent stimulatory and inhibitory effects of OP on the endocrine pituitary function.
The risks are often higher for children bereaved by loss of a core family member (i.e., older child or spouse) than by loss of an extended family member (i.e., mother's sibling or parent), suggesting the presence of dose-response effect.
To directly assess the functional role of p53 in camptothecin-induced apoptosis, c-Myc-overexpressing L2 and L3 cells were exposed to camptothecin in the presence of doses of PFT- α, a specific inhibitor of p53 (Komarov et al, 1999), that we have previously shown to inhibit 5FU-induced apoptosis in this system (Arango et al, 2001).
Figure 2 shows the arrhythmogenic dose and plasma concentration of epinephrine in the presence of subanesthetic dose of sevoflurane, isoflurane, halothane, and propofol and no anesthetics (control).
The high removal yields (76 % to 99%%) in short contact time of 30 min at the presence of low dose of adsorbent (0.05 to 0.1 g) are the precious advantages of modified silica aerogel.
However again, the presence of a dose gradient was not evaluated formally.
We measured retina explant neurite outgrowth in the presence of a dose range of sMHC(1 298) from transfected COS cells.
