The presence of binding sites for the glycoprotein ASF, whose glycans bind rather equally well to the human galectins [ 51], underscores this assumption.
HOMER motif searches25 revealed that promoter occupancy of LSD1 significantly correlates with the presence of binding sites for the transcription factor Nrf1 (Fig. 3a).
Consistent with the general theory of the second-best, the presence of binding political economy constraints opens a significant "opportunity space" for the design of creative climate policy instruments with superior political feasibility, economic efficiency, and environmental efficacy relative to the constrained implementation of carbon pricing policies.
The importance of the brainstem for the genesis of migraine is further underlined by the presence of binding sites for specific anti-migraine compounds within these structures [53].
For saturation analyses, 100 μg of cerebellar membrane protein and increasing concentrations of [3H]LY456066 [11] were added to quadruplicate wells in the presence of binding buffer (10 mM K2HPO4, 1.2 mM KH2PO4, 100 mM KCl, 0.1% DMSO, 0.05% ethanol and 0.1% BSA, pH 7.6).
Serum samples were tested throughout the experimental period for the presence of binding antibody to HIV Gag.
Additionally, this region contains most of the proteins' cysteine residues, which could reflect the presence of binding sites.
We checked for the presence of binding sites/responsive elements for chromatin remodelling factors and transcription factors (Genomatix®) in the Igf2r DMR (File S1).
A first step in evaluating target druggability is to detect the presence of binding pockets of suitable size, shape, and composition to accommodate drug-like molecules.
Binding reactions of in vitro translated proteins and GST-fused proteins were performed in the presence of binding buffer (20 mM Tris pH 8.0, 100 mM NaCl, 0.1% NP-40, 1 mM DTT) for 1 hr.
Thus the absence of activation of monomeric IDE in the presence of binding can be accounted for by the necessity of a conformational change induced by activator binding to one subunit and transmitted to the adjacent subunit.
